Women Have Lower Tonic Autonomic Support of Arterial Blood Pressure and Less Effective Baroreflex Buffering Than Men

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Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men.

BACKGROUND Short-term and tonic regulation of arterial blood pressure (BP) differ in premenopausal women and men of similar age. The autonomic nervous system (ANS) plays a critical role in BP regulation. METHODS AND RESULTS To test the hypothesis that women have lower tonic ANS support of BP (reduction in intra-arterial BP during acute ganglionic blockade [GB] with intravenous trimethaphan) a...

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Arterial Baroreflex Buffering

Static muscle contraction activates metabolically sensitive muscle afferents that reflexively increase sympathetic nerve activity and arterial pressure. To determine if this contractioninduced reflex is modulated by the sinoaortic baroreflex, we performed microelectrode recordings of sympathetic nerve activity to resting leg muscle during static handgrip in humans while attempting to clamp the ...

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Is Intra-Arterial Treatment for Acute Ischemic Stroke Less Effective in Women than in Men?

INTRODUCTION Stroke etiology and outcome after ischemic stroke differ between men and women. We examined if sex modifies the effect of intra-arterial treatment (IAT) in a randomized clinical trial of IAT for acute ischemic stroke in the Netherlands (MR CLEAN). PATIENTS AND METHODS The primary outcome was the score on the modified Rankin scale at 90 days. We tested for interaction between sex ...

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Altered autonomic support of arterial blood pressure with age in healthy men.

BACKGROUND Primary aging is associated with changes in the autonomic nervous system (ANS), but the functional significance of these changes for systemic circulatory control of arterial blood pressure (BP) is unknown. We tested the hypothesis that ANS support of BP is altered in healthy older humans. METHODS AND RESULTS A total of 23 young (aged 24+/-1 years; systolic/diastolic BP, 126+/-2/66+...

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Aging enhances autonomic support of blood pressure in women.

The autonomic nervous system plays a central role in both acute and chronic blood pressure regulation in humans. The activity of the sympathetic branch of the autonomic nervous system is positively associated with peripheral resistance, an important determinant of mean arterial pressure in men. In contrast, there is no association between sympathetic nerve activity and peripheral resistance in ...

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ژورنال

عنوان ژورنال: Circulation

سال: 2005

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.0000153864.24034.a6